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KMID : 1225720160080060505
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Allergy, Asthma & Immunology Research : AAIR
2016 Volume.8 No. 6 p.505 ~ p.511
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Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea
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Park Kyung-Hee
Son Young-Woong
Lee Sang-Chul
Jeong Kyung-Uk
Sim Da-Woon
Park Hye-Jung
Lee Soo-Young
Lee Jae-Hyun
Park Jung-Tak
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Abstract
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Purpose:Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy.
Methods:Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis).
Results:After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries.
Conclusions:Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy.
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KEYWORD
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Allergens, IgE, peanut hypersensitivity, pollen, trees
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